Q Chen A / Y Wang (@5.5) vs M Kawamura / F Kozaki (@1.12)

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M Kawamura / F Kozaki will win
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Q Chen A / Y Wang – M Kawamura / F Kozaki Match Prediction | 10-09-2019 02:30

Cheng, S.I. Kim, H.U. Zhang, J.-W. Song, W.-H. Webb, J.W. Cho, J.G. Dawidczyk, R.H. Han,S. Huang and J.A. Kim, R.C. Mathewson, Y.H. Lee, T.J. Gratton, Y.G. Chung, D.J. Kim, H.Y. Jeong, G.-T. Fabiani, G. Xu, K.E. Kim, Y.M. 33. Yeo, S. Lee, Y.Y. Chung, B.G. Jang, S.Y. Rugged and Breathable Forms of Stretchable Electronics with Adherent Composite Substrates for Transcutaneous Monitoring [pdf] K.-I. Rhee, J.H. Carbonari, M. Yang, M.G. Gaspar, R.

Both these options allow for the user to tailor and specify the miRNAs for investigation when looking into different pathways. The details option in the DIANA software allows the user to see which miRNAs were predicted to have statistical significance with each pathway. The results from the DIANA software revealed our miRNA lists had statistically significant interactions with pathways such as fatty acid biosynthesis and fatty acid metabolism. The software also predicted other more specific pathways of interest such as prostate cancer, colorectal cancer, bladder cancer and many others. Such results mutually strengthen both the evidence from literature of dietary modulated miRNAs and also the accuracy of prediction. This reduces the time needed to find miRNAs of interest. prostate cancer and generates a list of statistically significant miRNA interactions from the Tarbase v7.0 database. Other pathways such as proteoglycans in cancer and miRNAs in cancer consistently ranked among the most statistically significant pathways (Table 2 - Table 4). Furthermore, a reverse search option allows the user to input a pathway of interest, i.e. Interestingly, such pathways, which may seem irrelevant, have been shown in several studies to over-activate in cancers, causing increased energy uptake and metabolism whilst promoting clinically aggressive behaviour in tumours, tumour cell-growth and survival 68, 69, 70, 71, 72. Usually vast assays of miRNAs are assessed in order to see which have been altered, however the software does this for the researcher and thus decreases the need for time and resources for such assays. However, the software brings to light the need for further exploration under the lens of miRNA. While we focussed on cancer, other physiological pathways of interest could follow a similar model. When we consider the implications of this software, one of its strengths is in its vast database of experimentally supported interactions.

Yu, S.I. Jung, M. Huang and J.A. Luan, J.W. Kim, Y.H. Jeong, H.Y. Cho, F.X. Xu, C.H. Chung, B.G. Jang, H.U. Lee, J.H. Liu, G.W. Zhang, Y.G. Miao, Y.Y. Flavin, Y.H. Kim, M.G. Cheng, G.-T. Chung, S. Soft Network Composite Materials with Deterministic and Bio-Inspired Designs [pdf] K.-I. Kim, S.Y. Lee, H.W. 40. Yang, H.N. Kong, K.J. Han, J.W. Rhee, J.H.

We aimed to effectively evaluate the strength of evidence from the available literature regarding the usefulness of dietary bioactives whilst, simultaneously demonstrating the features of the DIANA software and its ability to synergistically strengthen data from the literature. To conclude, dietary bioactives modulate miRNA which in turn have effects on cancer development and progression. Rather than seeking a needle in a haystack, we liken the use of DIANA software together with Tarbase, as dramatically reducing the size of the miRNA pool to be investigated, to something more manageable from a logistical and financial point of view. Such evidence sourced from experimentally supported interactions as seen in Tarbase v7.0, implies that we can be relatively confident, keeping the limitations in mind, that the information provided can be applied in the laboratory to investigate diet-miRNA interactions in the context of cancers.

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The aims of conducting this in silico study were to effectively evaluate the strength of evidence for miRNA modulation by dietary bioactives. However, despite this knowledge, we are still only scratching the surface with respect to understanding how miRNAs are regulated, how they act individually and synergistically to modulate gene expression and in finding novel therapeutic treatments that are effective in regulating miRNA. There is no doubt from the plethora of evidence that miRNAs play a crucial role in cancer development.

Yan, X. Xu, M. Xie, A. Liu, J.W. Feng, S. Battery-free, Stretchable Optoelectronic Systems for Wireless Optical Characterization of the Skin [pdf]J. Sheng, Y.H. Zimmerman, J. Fabiani, G. Heo, K.Y. 42. Kim, L.Q. Jang, S.Y. Salvatore, H. Kim, G.A. Araki, A.M. Huang, U. Luo, B. Gratton, Y.G. Cho, H.Y. Banks, X. Chiarelli, Z.Q. Paik and J.A. Lee, K.-I.

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Ning, J. Kiggins, Y.Y. Sun, S. Busbee, Z.H. 45. Wang, P.C. Eaves, J. Electroplating Lithium Transition Metal Oxides [pdf]H.G. Zhang, H.L. Hong, Y.B. Hua, J. Zuo, X.H. Chan, S.B. Xu, J.Y. Shi, Y.-T. Davis III, T. Shen, C. Liu and P.V. Shao, J.-M. Wang, P.

MiR-194 has been shown to inhibit epithelial to mesenchymal transition (i.e. Additionally, it has also been shown to regulate the p53 mediated THBS1 gene (inhibitor of angiogenesis) post-transcriptionally, thereby playing a part in angiogenesis 64. Other miRNA such as miR-424 are more specific and are important for monocytic differentiation and leukaemia and regulation of the cell cycle by causing arrest at the G1 stage 65. Let-7b is known to act as a tumour suppressor by suppressing oncogenes influencing cell growth and motility 66. MiR-96-5p expression is up-regulated in several cancers, and in breast cancer cells this overexpression inhibited autophagy, promoted cell proliferation, migration and invasion 67. metastasis) and possesses anti-proliferative activity also through the p53 pathway 63. Finally, let-7b is often grouped under the let-7 family. Collectively, the modulation of these miRNA encompass a wide array of cellular functions which when aberrantly modified, lead to cancer development.


Importantly, when the DIANA software is compared to other software such as TargetScanHuman v7.1 66, the Tarbase based DIANA software helps overcome the high false positive rates seen in such softwares implementations which rely solely on in silico predictions by sourcing experimentally supported interactions. One of the main logistical advantages of the DIANA software is the ability to upload large lists of miRNA into the software to allow concurrent complex interactions to be calculated with algorithms, something which the TargetScanHuman fails to do. TargetScanHuman software in itself is a more difficult software to navigate with a smaller database of miRNAs. It predicts biological targets of miRNAs by searching for the presence of conserved (miRNA found in multiple species) sites that match the seed region of each miRNA 67 and predicts efficacy of targeting using cumulative weighted context++ scores of the sites 66 as opposed to using p values

Xu, G. Azam, S. Tang, Y.-H. Yen, J. Wang, T.M. Lee, S.S. Liu and R. Lo, B.P. Wang, H.M. Array Atomic Force Microscope for Real-Time Multiparametric Analysis [pdf]Q.Q. McCulloch, S. John, Z.W. Ma, K.M. Cauwenberghs, A.D. Wang, N. Yang, Q. Herum, C.H. Patel, J. 55. Head, F.